GENETIC PREDISPOSITIONS IN AGGRESSIVE PERIODONTITIS: A SYSTEMATIC REVIEW

Abstract

This systematic review assessed the genetic predispositions linked to aggressive periodontitis by examining 32 qualifying studies from various populations. Notable correlations were found for cytokine gene polymorphisms such as IL-1β +3954 C/T and TNF-α –308 G/A, as well as immune-regulatory variants including TLR4 Asp299Gly and CD14 −159 C/T. Mutations in neutrophil-related genes, especially CTSC, exhibited significant associations with severe generalised AgP. The results emphasise the complex genetic factors contributing to susceptibility to aggressive periodontitis. However, population heterogeneity and methodological discrepancies underscore the necessity for more standardised genetic research.